How Much Protein on GLP-1 Medications

Protein targets, food choices, and practical strategies for hitting 1.5–2.0 g/kg while on semaglutide or tirzepatide — even with a very small appetite.

Evidence & references

Reviewed and updated

This is a medically sensitive topic. The guide is educational, was checked against the sources below, and does not replace individual advice from your doctor, midwife or dietitian.

Sources

  1. 1.SURMOUNT-1 body composition analysis, 2025. Body composition changes during weight reduction with tirzepatide. Diabetes, Obesity and Metabolism, 27(5).
  2. 2.Blundell et al., 2017. Effects of once-weekly semaglutide on appetite, energy intake and body weight in obesity. Diabetes, Obesity and Metabolism, 19(9), 1242-1251.
  3. 3.Narrative review, 2026. Micronutrient and nutritional deficiencies associated with GLP-1 receptor agonist therapy. Clinical Obesity.
  4. 4.Mettler, Mitchell & Tipton, 2010. Increased protein intake reduces lean body mass loss during weight loss in athletes. Medicine & Science in Sports & Exercise, 42(2), 326-337.
  5. 5.Morton et al., 2018. Systematic review, meta-analysis and meta-regression of protein supplementation and resistance-training gains. British Journal of Sports Medicine, 52(6), 376-384.
  6. 6.Bauer et al., 2013. Evidence-based recommendations for optimal dietary protein intake in older people (PROT-AGE). Journal of the American Medical Directors Association, 14(8), 542-559.